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Structural Determination of Catalytically Active Subnanometer Iron Oxide Clusters

Supported subnanometer clusters exhibit superiority in catalytic performance compared to common nanoparticles, due to their higher fraction of exposed surfaces and larger number of active species at the metal–support interface, responding to the size effect and the support effect in heterogeneous catalysis. 26-04-2016
　　Supported subnanometer clusters exhibit superiority in catalytic performance compared to common nanoparticles, due to their higher fraction of exposed surfaces and larger number of active species at the metal–support interface, responding to the size effect and the support effect in heterogeneous catalysis. Here, we report the synthesis of subnanometer iron oxide clusters anchored to the surfaces of two types of ceria nanoshapes (nanorods and nanopolyhedra), as well as the str...

04 27 , 2016
Homogeneously Dispersed, Multimetal Oxygen-evolving Catalysts

Earth-abundant first-row (3d) transition-metal-based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials significantly above thermodynamic requirements. Density functional theory suggested that non-3d high-valency metals such as tungsten can modulate 3d metal oxides, providing near-optimal adsorption energies for OER intermediates. 08-04-2016
　　Earth-abundant first-row (3d) transition-metal-based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials significantly above thermodynamic requirements. Density functional theory suggested that non-3d high-valency metals such as tungsten can modulate 3d metal oxides, providing near-optimal adsorption energies for OER intermediates. We developed a room-temperature synthesis to produce gelled oxy-hydroxide materials with ...

04 13 , 2016
Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in humans and primates. Understanding how these viruses enter host cells could help to develop effective therapeutics. An endosomal protein, Niemann-Pick C1 (NPC1), has been identified as a necessary entry receptor for this process, and priming of the viral glycoprotein (GP) to a fusion-competent state is a prerequisite for NPC1 binding. 19-01-2016
　　Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in humans and primates. Understanding how these viruses enter host cells could help to develop effective therapeutics. An endosomal protein, Niemann-Pick C1 (NPC1), has been identified as a necessary entry receptor for this process, and priming of the viral glycoprotein (GP) to a fusion-competent state is a prerequisite for NPC1 binding. Here, we have determined the crystal structure of the primed GP ...

01 27 , 2016
Base-Induced Liquid Crystals of Graphene Oxide for Preparing Elastic Graphene Foams with Long-Range Ordered Microstructures

Base-induced graphene oxide (GO) liquid crystals form a highly ordered texture. This microstructure can be inherited to the graphene foams prepared by hydrothermal reduction, showing long-range ordered microstructure of graphene sheets in 3D. This provides an insightful understanding into the supramolecular chemistry of GO sheets. 14-01-2016
　　Base-induced graphene oxide (GO) liquid crystals form a highly ordered texture. This microstructure can be inherited to the graphene foams prepared by hydrothermal reduction, showing long-range ordered microstructure of graphene sheets in 3D. This provides an insightful understanding into the supramolecular chemistry of GO sheets.The research was conducted at the BL16B1 beamline of the SSRF.
　　(a) POM images of a 3.5 mg mL−1 GO suspension containing 0.132 m KOH n...

01 27 , 2016
Structural Insight into Substrate Preference for TET-mediated Oxidation

DNA methylation is an important epigenetic modification. Ten-eleven translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Here we show that human TET1 and TET2 are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. 02-11-2015
　　DNA methylation is an important epigenetic modification. Ten-eleven translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Here we show that human TET1 and TET2 are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. We determine the crystal structures of TET2–5hmC-DNA and TET2–5fC-DNA complexes at 1.80 Å and 1.97...

11 10 , 2015
Allosteric Receptor Activation by the Plant Peptide Hormone Phytosulfokine

Phytosulfokine (PSK) is a disulfated pentapeptide that has a ubiquitous role in plant growth and development. PSK is perceived by its receptor PSKR, a leucine-rich repeat receptor kinase (LRR-RK). The mechanisms underlying the recognition of PSK, the activation of PSKR and the identity of the components downstream of the initial binding remain elusive. 08-10-2015
　　Phytosulfokine (PSK) is a disulfated pentapeptide that has a ubiquitous role in plant growth and development. PSK is perceived by its receptor PSKR, a leucine-rich repeat receptor kinase (LRR-RK). The mechanisms underlying the recognition of PSK, the activation of PSKR and the identity of the components downstream of the initial binding remain elusive. Here we report the crystal structures of the extracellular LRR domain of PSKR in free, PSK- and co-receptor-bound forms...

10 08 , 2015

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