Science Highlights----上海光源（英文版）

Research

Home ResearchScience Highlights

Science Highlights

The Bacteriophage 29 Tail Possesses a Pore-forming Loop for Cell Membrane Penetration

Most bacteriophages are tailed bacteriophages with an isometric or a prolate head attached to a long contractile, long non-contractile, or short non-contractile tail. The tail is a complex machine that plays a central role in host cell recognition and attachment, cell wall and membrane penetration, and viral genome ejection. 08-07-2016
　　Most bacteriophages are tailed bacteriophages with an isometric or a prolate head attached to a long contractile, long non-contractile, or short non-contractile tail. The tail is a complex machine that plays a central role in host cell recognition and attachment, cell wall and membrane penetration, and viral genome ejection. The mechanisms involved in the penetration of the inner host cell membrane by bacteriophage tails are not well understood. Here we describe structural and ...

07 08 , 2016
Structural Basis of N6-adenosine Methylation by the METTL3–METTL14 Complex

Chemical modifications of RNA have essential roles in a vast range of cellular processes. N6-methyladenosine (m6A) is an abundant internal modification in messenger RNA and long non-coding RNA that can be dynamically added and removed by RNA methyltransferases (MTases) and demethylases, respectively. 08-07-2016
　　Chemical modifications of RNA have essential roles in a vast range of cellular processes. N6-methyladenosine (m6A) is an abundant internal modification in messenger RNA and long non-coding RNA that can be dynamically added and removed by RNA methyltransferases (MTases) and demethylases, respectively. An MTase complex comprising methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) efficiently catalyses methyl group transfer. In contrast to the well-studied D...

07 08 , 2016
FeO2 and FeOOH Under Deep Lower-mantle Conditions and Earth’s Oxygen–hydrogen Cycles

The distribution, accumulation and circulation of oxygen and hydrogen in Earth’s interior dictate the geochemical evolution of the hydrosphere, atmosphere and biosphere. The oxygen-rich atmosphere and iron-rich core represent two end-members of the oxygen–iron (O–Fe) system, overlapping with the entire pressure–temperature–composition range of the planet. 22-06-2016
　　The distribution, accumulation and circulation of oxygen and hydrogen in Earth’s interior dictate the geochemical evolution of the hydrosphere, atmosphere and biosphere. The oxygen-rich atmosphere and iron-rich core represent two end-members of the oxygen–iron (O–Fe) system, overlapping with the entire pressure–temperature–composition range of the planet. The extreme pressure and temperature conditions of the deep interior alter the oxidation states, spin states and phase ...

06 24 , 2016
Photochemical Route for Synthesizing Atomically Dispersed Palladium Catalysts

Atomically dispersed noble metal catalysts often exhibit high catalytic performances, but the metal loading density must be kept low (usually below 0.5%) to avoid the formation of metal nanoparticles through sintering. We report a photochemical strategy to fabricate a stable atomically dispersed palladium–titanium oxide catalyst 01-06-2016
　　Atomically dispersed noble metal catalysts often exhibit high catalytic performances, but the metal loading density must be kept low (usually below 0.5%) to avoid the formation of metal nanoparticles through sintering. We report a photochemical strategy to fabricate a stable atomically dispersed palladium–titanium oxide catalyst (Pd1/TiO2) on ethylene glycolate (EG)–stabilized ultrathin TiO2 nanosheets containing Pd up to 1.5%. The Pd1/TiO2 catalyst exhibited high catalytic a...

06 03 , 2016
The Crystal Structure of Cpf1 in Complex with CRISPR RNA

The CRISPR–Cas systems, as exemplified by CRISPR–Cas9, are RNA-guided adaptive immune systems used by bacteria and archaea to defend against viral infection. The CRISPR–Cpf1 system, a new class 2 CRISPR–Cas system, mediates robust DNA interference in human cells. Although functionally conserved, Cpf1 and Cas9 differ in many aspects including their guide RNAs and substrate specificity. 26-04-2016
　　The CRISPR–Cas systems, as exemplified by CRISPR–Cas9, are RNA-guided adaptive immune systems used by bacteria and archaea to defend against viral infection. The CRISPR–Cpf1 system, a new class 2 CRISPR–Cas system, mediates robust DNA interference in human cells. Although functionally conserved, Cpf1 and Cas9 differ in many aspects including their guide RNAs and substrate specificity. Here we report the 2.38 Å crystal structure of the CRISPR RNA (crRNA)-bound Lachnospirac...

04 27 , 2016
Zika Virus NS1 Structure Reveals Diversity of Electrostatic Surfaces among Flaviviruses

The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. 26-04-2016
　　The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfa...

04 27 , 2016

Home prev 1 2 345 next End

more