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Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in humans and primates. Understanding how these viruses enter host cells could help to develop effective therapeutics. An endosomal protein, Niemann-Pick C1 (NPC1), has been identified as a necessary entry receptor for this process, and priming of the viral glycoprotein (GP) to a fusion-competent state is a prerequisite for NPC1 binding. 19-01-2016Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in humans and primates. Understanding how these viruses enter host cells could help to develop effective therapeutics. An endosomal protein, Niemann-Pick C1 (NPC1), has been identified as a necessary entry receptor for this process, and priming of the viral glycoprotein (GP) to a fusion-competent state is a prerequisite for NPC1 binding. Here, we have determined the crystal structure of the primed GP (GPcl...

01 27 , 2016
Base-Induced Liquid Crystals of Graphene Oxide for Preparing Elastic Graphene Foams with Long-Range Ordered Microstructures

Base-induced graphene oxide (GO) liquid crystals form a highly ordered texture. This microstructure can be inherited to the graphene foams prepared by hydrothermal reduction, showing long-range ordered microstructure of graphene sheets in 3D. This provides an insightful understanding into the supramolecular chemistry of GO sheets. 14-01-2016Base-induced graphene oxide (GO) liquid crystals form a highly ordered texture. This microstructure can be inherited to the graphene foams prepared by hydrothermal reduction, showing long-range ordered microstructure of graphene sheets in 3D. This provides an insightful understanding into the supramolecular chemistry of GO sheets.The research was conducted at the BL16B1 beamline of the SSRF.(a) POM images of a 3.5 mg mL−1 GO suspension containing 0.132 m KOH near the in...

01 27 , 2016
Structural Insight into Substrate Preference for TET-mediated Oxidation

DNA methylation is an important epigenetic modification. Ten-eleven translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Here we show that human TET1 and TET2 are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. 02-11-2015DNA methylation is an important epigenetic modification. Ten-eleven translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Here we show that human TET1 and TET2 are more active on 5mC-DNA than 5hmC/5fC-DNA substrates. We determine the crystal structures of TET2–5hmC-DNA and TET2–5fC-DNA complexes at 1.80 Å and 1.97 Å ...

11 10 , 2015
Allosteric Receptor Activation by the Plant Peptide Hormone Phytosulfokine

Phytosulfokine (PSK) is a disulfated pentapeptide that has a ubiquitous role in plant growth and development. PSK is perceived by its receptor PSKR, a leucine-rich repeat receptor kinase (LRR-RK). The mechanisms underlying the recognition of PSK, the activation of PSKR and the identity of the components downstream of the initial binding remain elusive. 08-10-2015Phytosulfokine (PSK) is a disulfated pentapeptide that has a ubiquitous role in plant growth and development. PSK is perceived by its receptor PSKR, a leucine-rich repeat receptor kinase (LRR-RK). The mechanisms underlying the recognition of PSK, the activation of PSKR and the identity of the components downstream of the initial binding remain elusive. Here we report the crystal structures of the extracellular LRR domain of PSKR in free, PSK- and co-receptor-bound forms. The...

10 08 , 2015
Strong Local Coordination Structure Effects on Subnanometer PtOx Clusters over CeO2 Nanowires Probed by Low-Temperature CO Oxidation

In this work, we report the strong effects of local coordination structures on the catalytic activity of subnanometric PtOx clusters over CeO2 nanowires in low-temperature CO oxidation as a probe reaction. 17-09-2015A fundamental understanding of the structural effects of supported metal catalysts at the molecular level is extremely important for developing high-performance catalysts that are widely used in industry, which is still a longstanding attractive but challenging topic in multidisciplinary fields. In this work, we report the strong effects of local coordination structures on the catalytic activity of subnanometric PtOx clusters over CeO2 nanowires in low-temperature CO oxidation as a ...

09 17 , 2015
Multiply Confined Nickel Nanocatalysts Produced by Atomic Layer Deposition for Hydrogenation Reactions

To design highly efficient catalysts, new concepts for optimizing the metal–support interactions are desirable. Here we introduce a facile and general template approach assisted by atomic layer deposition (ALD), to fabricate a multiply confined Ni-based nanocatalyst. 01-09-2015To design highly efficient catalysts, new concepts for optimizing the metal–support interactions are desirable. Here we introduce a facile and general template approach assisted by atomic layer deposition (ALD), to fabricate a multiply confined Ni-based nanocatalyst. The Ni nanoparticles are not only confined in Al2O3 nanotubes, but also embedded in the cavities of Al2O3 interior wall. The cavities create more Ni–Al2O3 interfacial sites, which facilitate hydrogenatio...

09 01 , 2015

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